Abstract: The assault of free radicals and imbalance in oxidant and antioxidant status leads to the induction of diseases from cancers to neuro-degenerative diseases. Natural antioxidants can put a secured check over free radicals and the damages induced by them at various levels. Seaweeds are rich in bioactive compounds like sulfated polysaccharides, phlorotannins and diterpenes which are benefit for both human health applications. Turbinaria ornata, the spiny leaf seaweed has been studied for its antioxidant, antiulcer, wound healing and hepatoprotective activities. In the present study, phytochemicals analysis, in vitro antioxidant and anti-hemolysis activity of Turbinaria ornata methanolic extract (TOME) in RBC model was done. The results reveal the presence of carbohydrates, alkaloids, saponins, phenolic compounds, flavonoids, tannins, coumarines, steroids and terpenoids. The UV-Vis, FTIR and GCMS analysis also elucidates the presence of phenolics and important bioactive compounds in TOME, which exhibits appreciable antioxidant activity and prevents H2O2 induced hemolysis in human RBC model by maintaining the cell membrane integrity.

Keywords: Turbinaria ornata, invitro antioxidant avtivity, antihemolysis, bioactive compounds.